Does bottles support wine-ge-custom?

Not too sure if I can use bottles with wine-ge-custom or I should use Lutris with wine-ge-custom instead and how to configure it if possible?

And which one would give me more performance, bottles without wine-ge-custom or with wine-ge-custom?

You can use whatever runner you can place in Bottles directory. Though I don’t know if it’s needed if we look at how many runners Bottles already offers withing one click installation: Soda, Caffe, Vaniglia, Wine GE, Kron4ek, Lutris, Proton GE.
Something for sure will meet your needs.

That all depends on your PC, OS and even on specific programs/games. And also a runner because some can work better than others and vice versa.

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